X

Download Targeting the Underlying Pathophysiology of Type 2 Diabetes PowerPoint Presentation

SlidesFinder-Advertising-Design.jpg

Login   OR  Register
X


Iframe embed code :



Presentation url :

Home / Health & Wellness / Health & Wellness Presentations / Targeting the Underlying Pathophysiology of Type 2 Diabetes PowerPoint Presentation

Targeting the Underlying Pathophysiology of Type 2 Diabetes PowerPoint Presentation

Ppt Presentation Embed Code   Zoom Ppt Presentation

PowerPoint is the world's most popular presentation software which can let you create professional Targeting the Underlying Pathophysiology of Type 2 Diabetes powerpoint presentation easily and in no time. This helps you give your presentation on Targeting the Underlying Pathophysiology of Type 2 Diabetes in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.

The uploader spent his/her valuable time to create this Targeting the Underlying Pathophysiology of Type 2 Diabetes powerpoint presentation slides, to share his/her useful content with the world. This ppt presentation uploaded by onlinesearch in Health & Wellness ppt presentation category is available for free download,and can be used according to your industries like finance, marketing, education, health and many more.

About This Presentation

Targeting the Underlying Pathophysiology of Type 2 Diabetes Presentation Transcript

Slide 1 - Targeting the Underlying Pathophysiology of Type 2 Diabetes
Slide 2 - Aim Provide practical guidance on improving diabetes care through highlighting the need to: understand that insulin resistance and b-cell dysfunction are core defects of type 2 diabetes address the underlying pathophysiology
Slide 3 - Type 2 diabetes Characterized by chronic hyperglycemia Associated with microvascular and macrovascular complications Generally arises from a combination of insulin resistance and -cell dysfunction Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Department of Noncommunicable Disease Surveillance,World Health Organization, Geneva 1999. Available at: http://www.diabetes.org.uk/infocentre/carerec/diagnosi.doc
Slide 4 - Major defect in individuals with type 2 diabetes1 Reduced biological response to insulin1–3 Strong predictor of type 2 diabetes4 Closely associated with obesity5 What is insulin resistance? 1American Diabetes Association. Diabetes Care 1998; 21:310–314. 2Beck-Nielsen H & Groop LC. J Clin Invest 1994; 94:1714–1721. 3Bloomgarden ZT. Clin Ther 1998; 20:216–231. 4Haffner SM, et al. Circulation 2000; 101:975–980. 5Boden G. Diabetes 1997; 46:3–10.
Slide 5 - What is -cell dysfunction? Major defect in individuals with type 2 diabetes Reduced ability of -cells to secrete insulin in response to hyperglycemia DeFronzo RA, et al. Diabetes Care 1992; 15:318–354.
Slide 6 - Insulin resistance and -cell dysfunction are core defects of type 2 diabetes Rhodes CJ & White MF. Eur J Clin Invest 2002; 32 (Suppl. 3):3–13.
Slide 7 - How do insulin resistance and -cell dysfunction combine to cause type 2 diabetes?
Slide 8 - Several methods exist, including: continuous sampling of insulin/glucose1 gold standard, but impractical for large-scale use single measure of insulin/glucose2 simple estimate from fasting insulin and glucose useful for assessment on a larger scale How is insulin resistance measured? 1Bergman RN, et al. Eur J Clin Invest 2002; 32 (Suppl. 3):35–45. 2Matthews DR, et al. Diabetologia 1985; 28:412–419.
Slide 9 - More than 80% of patients progressing to type 2 diabetes are insulin resistant Insulin resistant;low insulin secretion (54%) Insulin resistant; good insulin secretion (29%) Insulin sensitive;good insulin secretion (1%) Insulin sensitive;low insulin secretion (16%) 83% Haffner SM, et al. Circulation 2000; 101:975–980.
Slide 10 - Insulin resistance – reduced response to circulating insulin Insulin resistance  Glucose output  Glucose uptake  Glucose uptake Hyperglycemia Liver Muscle Adiposetissue
Slide 11 - Overall, 75% of patients with type 2 diabetes die from cardiovascular disease Gray RP & Yudkin JS. Cardiovascular disease in diabetes mellitus. In Textbook of Diabetes 2nd Edition, 1997. Blackwell Sciences.
Slide 12 - Insulin resistance is as strong a risk factor for cardiovascular disease as smoking 0.6 0.8 1.0 1.2 1.4 1.6 1.8 Odds ratio for incident CVD Age Smoking Total cholesterol:HDL cholesterol Insulinresistance Bonora E, et al. Diabetes Care 2002; 25:1135–1141.
Slide 13 - Insulin resistance is closely linked to cardiovascular disease Present in > 80% of people with type 2 diabetes1 Approximately doubles the risk of a cardiac event2 Implicated in almost half of CHD events in individuals with type 2 diabetes2 Insulin resistance 1Haffner SM, et al. Circulation 2000; 101:975–980. 2Strutton D, et al. Am J Man Care 2001; 7:765–773.
Slide 14 - Insulin resistance is linked to a range of cardiovascular risk factors Zimmet P. Trends Cardiovasc Med 2002; 12:354–362.
Slide 15 - ~90% of people with type 2 diabetes are overweight or obese World Health Organization, 2005. http://www.who.int/dietphysicalactivity/publications/facts/obesity
Slide 16 - How is -cell function measured? -cell function is difficult to measure and most methods are impractical for large-scale use1 Homeostasis model assessment (HOMA) provides a simple estimate of -cell function2 Proinsulin:insulin ratio is sometimes used as a marker of -cell dysfunction1 1Matthews DR, et al. Diabetologia 1985; 28:412–419. 2Bergman RN, et al. Eur J Clin Invest 2002; 32 (Suppl. 3):35–45.
Slide 17 - Why does the -cell fail? Chronic hyperglycemia Oversecretion of insulin to compensate for insulin resistance1,2 High circulating free fatty acids Glucotoxicity2 Pancreas Lipotoxicity3 -cell dysfunction 1Boden G & Shulman GI. Eur J Clin Invest 2002; 32:14–23. 2Kaiser N, et al. J Pediatr Endocrinol Metab 2003; 16:5–22. 3Finegood DT & Topp B. Diabetes Obes Metab 2001; 3 (Suppl. 1):S20–S27.
Slide 18 - Glycemic control declines over time 9 8 7 6 0 UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352:837–853.
Slide 19 - Loss of -cell function occurs before diagnosis Time from diagnosis (years) Up to 50% loss 100 80 60 40 -cell function (%) 20 0 Diagnosis -10 -9 -8 -7 -6 -5 -4 -3 -2 -1 1 2 3 4 5 6 Holman RR. Diabetes Res Clin Prac 1998; 40 (Suppl.):S21–S25.
Slide 20 - Oral antidiabetic agents – do they target insulin resistance and -cell dysfunction?
Slide 21 - Barriers to achieving good glycemic control Inadequate targeting of underlying pathophysiology
Slide 22 - Primary sites of action of oral antidiabetic agents  Glucose output  Insulin resistance Biguanides  Insulin resistance Thiazolidinediones Kobayashi M. Diabetes Obes Metab 1999; 1 (Suppl. 1):S32–S40. Nattrass M & Bailey CJ. Baillieres Best Pract Res Clin Endocrinol Metab 1999; 13:309–329.
Slide 23 - The dual action of thiazolidinediones reduces HbA1c + HbA1c Insulin resistance -cell function Lebovitz HE, et al. J Clin Endocrinol Metab 2001; 86:280–288.
Slide 24 - Potential to prevent progression to type 2 diabetes in at-risk women Troglitazone reduced progression to type 2 diabetes by > 50% Proportion with diabetes 0.5 0.6 0.4 0.3 0.2 0.1 0.0 Time on trial (months) 10 0 20 30 40 50 60 Placebo Troglitazone* 400 mg/day Buchanan TA, et al. Diabetes 2002; 51:2796–2803. *Troglitazone is no longer available
Slide 25 - Subjects (%) 100 Screening 80 60 40 20 0 Week 12 Screening Week 12 Placebo Rosiglitazone 8 mg/day IGT 100% IGT 89% T2DM 11% IGT 100% NGT 44% IGT 56% Can thiazolidinediones delay progression from IGT to T2DM? Bennett SM, et al. Diabet Med 2004; 21:415–422.
Slide 26 - Does decreasing insulin resistance decrease macrovascular complications? UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352:854–865.
Slide 27 - Insulin sensitizers reduce cardiovascular events in type 2 diabetes 12-month combined event rate (%) 0 10 20 30 40 Non-sensitizers Sensitizers 50 60 Kao JA, et al. J Am Coll Cardiol 2004; 43:37A.
Slide 28 - How can diabetes care and outcomes be improved? The Global Partnership recommends: Address the underlying pathophysiology, including treatment of insulin resistance Del Prato S, et al. Int J Clin Pract 2005; 59:1345–1355.
 

Frequently Asked Questions

> About SlidesFinder?

Slidesfinder is a website that allows users to upload and share their PowerPoint presentations online. It provides a platform for individuals and businesses to share their ideas and knowledge through presentations, and for others to view and download these presentations for educational or professional purposes.
Slidesfinder offers a wide range of presentation topics and categories, including business, education, science, technology, health, and more. Users can also search for presentations using keywords, tags, or by category. The website provides tools to create professional presentations with rich media, animations, and graphics.



One of the key features of Slidesfinder is its user-friendly interface, which allows users to easily upload, view, and share presentations. Users can also embed their presentations in their websites or blogs using the website's embed code feature.
Slidesfinder also offers premium services, such as the ability to create private presentations and to download presentations in high-quality formats. However, the basic features of Slidesfinder are free to use, making it accessible to anyone who wants to share their ideas and knowledge through presentations.

> How do I register with SlidesFinder?

Go to registration page (you can see signup link on top of website page) https://www.slidesfinder.com/signup . If you have facebook/gmail account them just click on SIGN IN WITH FACEBOOK OR SIGN IN WITH GOOGLE button, by this you will be a registered member of slidesfinder without filling any form, required detail automatically will be fatch from your account. If you do not a Facebook account, then click on "Signup". Fill all required fields and you will be a registered member of slidesfinder.

> Is slidesfinder account confirmation is mandatory?

Yes it is mandetory to active your account to login.

> Do I need to signup/login on SlidesFinder before uploading a PowerPoint presentation?

Yes, you need to login with your account before uploading presentation. Your username will be displayed on your uploaded presentation. Your registered email id is needed for sending your stats of uploaded presentation.

Slidesfinder is a sharing website for PowerPoint presentations search and share. Find your interest in the form of powerpoint presentations on slidesfinder and save your valuable time . On Slidesfinder you get presentations from our huge library of professional ppt presentations. We believe in making your search INFORMATIVE and FUN. Find your best ppt presentation from a pool of PowerPoint presentations stacked under important industry categories like business & management, heath & Wellness,eduction & training etc. We provide unique informative PowerPoint presentation for marketers, presenters and educationists. These professional PowerPoint presentations are uploaded by professionals from across numerous industry segments.These ppt presentations are available for FREE download.

Not just finding your interest, but facilitate you broadcast your interest. We have created this platform for easy sharing of PowerPoint presentations, ensuring that these presentations get maximum exposure. Create your slidesfinder account and upload PowerPoint presentations for free, share on social media platforms and BUILD YOUR CROWD WITH PRESENTATION !!

The Great Buddha says, "Share your knowledge.It’s a way to achieve immortality"! So, start sharing knowledge and we are here to make that immortal !!

© 2013-2024 SlidesFinder. All rights reserved.

Re-productivity of content are not allowed. Without prior written permission from author, commercial use of any content is illegal.