X

Download Non Hodgkin Lymphoma Showing Abnormalities of c myc Including PowerPoint Presentation

SlidesFinder-Advertising-Design.jpg

Login   OR  Register
X


Iframe embed code :



Presentation url :

Home / Health & Wellness / Health & Wellness Presentations / Non Hodgkin Lymphoma Showing Abnormalities of c myc Including PowerPoint Presentation

Non Hodgkin Lymphoma Showing Abnormalities of c myc Including PowerPoint Presentation

Ppt Presentation Embed Code   Zoom Ppt Presentation

PowerPoint is the world's most popular presentation software which can let you create professional Non Hodgkin Lymphoma Showing Abnormalities of c myc Including powerpoint presentation easily and in no time. This helps you give your presentation on Non Hodgkin Lymphoma Showing Abnormalities of c myc Including in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.

The uploader spent his/her valuable time to create this Non Hodgkin Lymphoma Showing Abnormalities of c myc Including powerpoint presentation slides, to share his/her useful content with the world. This ppt presentation uploaded by slidesfinder in Health & Wellness ppt presentation category is available for free download,and can be used according to your industries like finance, marketing, education, health and many more.

About This Presentation

Non Hodgkin Lymphoma Showing Abnormalities of c myc Including Presentation Transcript

Slide 1 - Non-Hodgkin Lymphoma Showing Abnormalities of c-myc Including Dual Translocations Involving c-myc and Bcl-2: A Clinicopathologic Study R Jastania, V Kukreti, M AlShraim, D Bailey, B Patterson, M Crump, S Boerner, W Geddie University Health Network, Toronto, Ontario, Canada Introduction: Non-Hodgkin’s lymphomas (NHL) with translocations or amplification of c-myc are known to have a poor prognosis, specially when t(14;18) translocation, Bcl-2 is also present. Many of these cases, however, are classified as diffuse large B-cell lymphoma (DLBCL). In this study we review cases of non-Hodgkin’s lymphomas that show c-myc translocations or amplification (excluding cases of Burkitt’s lymphoma) to determine features that would predict the need for testing for these translocations at presentation. Materials and Methods:   A cytogenetic database (2002-2005) was reviewed to find cases assessed by a Vysis dual colour break-apart probe for c-myc (8q24.1). 27 patients were identified that did not fulfill criteria for diagnosis of Burkitt’s or atypical Burkitt’s lymphoma but had cytogenetic abnormalities of c-myc on FISH. Microscopy was reviewed by two pathologists and correlated with immunophenotypic, clinical and FISH data. Results: The age range was 26-83 years. 67% had stage 3-4 disease, 38% had B symptoms and 30% CNS involvement. 24 cases were diagnosed as DLBCL, and 3 as follicular lymphoma, grade3/3. 15 cases showed rearrangement of c-myc (Group1) and 12 cases showed only extracopies of (Group2). 8 patients showed combined t(14;18) and c-myc translocation. The majority of DLBCL’s were centroblstic. University of Toronto Results: Most cases showed moderate to severe pleomorphism with some bizarre forms but two were monomorphic centroblastic. All cases with dual translocations showed bright sIg, moderate CD19 and CD20 and bright CD10. No other immunophenotypic markers showed consistent pattern. MIB1 positive cells ranged form 60-90%. All patients treated with anthracycline-based chemotherapy. 3 from Group1 and 5 form Group2 are currently in complete remission with follow up less than one year. Median survival of the remaining patients in Group1 was 9 months (range 1-13), and in Group2 was 5 months (range1-21). Discussion: Lymphomas in general represent examples of malignancies associated with reproducible genetic abnormalities. Although not defining criteria, these genetic abnormalities are part of the diagnostic work in most lymphomas, and help in predicting the prognosis. The c-myc translocation, t(8;14) is the typical cytogenetic finding in sporadic cases of Burkitt lymphoma, and it is also described in the cases of atypical Burkitt lymphoma and a subset of DLBCL and in transformation of follicular lymphoma. The genetic heterogeneity of atypical Burkitt lymphoma and lack of restriction of the c-myc translocations to a homogeneous lymphoma type limit the usefulness of c-myc translocation as a discriminating marker of any single lymphoma type. In a study of cases of “Burkitt-like” lymphomas (BLL), it was shown that there was a difference in the survival in regard to the cytogenetic findings for c-myc and Bcl-2 translocations, and the survival declined in the order of: Bcl-2 translocation only, c-myc translocation only, both Bcl-2 and c-myc translocation, the last being the worst survival. Conclusion: Both c-myc gene rearrangement and extra copies of c-myc appear to confer poor prognosis in NHL. Not all patients with extra copies or translocation of c-myc satisfy criteria of Burkitt’s or atypical Burkitt’s lymphoma and they show no consistent morphologic findings to distinguish them from other DLBCL’s. Testing for c-myc abnormalities by FISH should be initiated in NHL patients with unusually aggressive clinical behaviour and patients with follicular lymphoma in transformation.
 

Frequently Asked Questions

> About SlidesFinder?

Slidesfinder is a website that allows users to upload and share their PowerPoint presentations online. It provides a platform for individuals and businesses to share their ideas and knowledge through presentations, and for others to view and download these presentations for educational or professional purposes.
Slidesfinder offers a wide range of presentation topics and categories, including business, education, science, technology, health, and more. Users can also search for presentations using keywords, tags, or by category. The website provides tools to create professional presentations with rich media, animations, and graphics.



One of the key features of Slidesfinder is its user-friendly interface, which allows users to easily upload, view, and share presentations. Users can also embed their presentations in their websites or blogs using the website's embed code feature.
Slidesfinder also offers premium services, such as the ability to create private presentations and to download presentations in high-quality formats. However, the basic features of Slidesfinder are free to use, making it accessible to anyone who wants to share their ideas and knowledge through presentations.

> How do I register with SlidesFinder?

Go to registration page (you can see signup link on top of website page) https://www.slidesfinder.com/signup . If you have facebook/gmail account them just click on SIGN IN WITH FACEBOOK OR SIGN IN WITH GOOGLE button, by this you will be a registered member of slidesfinder without filling any form, required detail automatically will be fatch from your account. If you do not a Facebook account, then click on "Signup". Fill all required fields and you will be a registered member of slidesfinder.

> Is slidesfinder account confirmation is mandatory?

Yes it is mandetory to active your account to login.

> Do I need to signup/login on SlidesFinder before uploading a PowerPoint presentation?

Yes, you need to login with your account before uploading presentation. Your username will be displayed on your uploaded presentation. Your registered email id is needed for sending your stats of uploaded presentation.

Slidesfinder is a sharing website for PowerPoint presentations search and share. Find your interest in the form of powerpoint presentations on slidesfinder and save your valuable time . On Slidesfinder you get presentations from our huge library of professional ppt presentations. We believe in making your search INFORMATIVE and FUN. Find your best ppt presentation from a pool of PowerPoint presentations stacked under important industry categories like business & management, heath & Wellness,eduction & training etc. We provide unique informative PowerPoint presentation for marketers, presenters and educationists. These professional PowerPoint presentations are uploaded by professionals from across numerous industry segments.These ppt presentations are available for FREE download.

Not just finding your interest, but facilitate you broadcast your interest. We have created this platform for easy sharing of PowerPoint presentations, ensuring that these presentations get maximum exposure. Create your slidesfinder account and upload PowerPoint presentations for free, share on social media platforms and BUILD YOUR CROWD WITH PRESENTATION !!

The Great Buddha says, "Share your knowledge.It’s a way to achieve immortality"! So, start sharing knowledge and we are here to make that immortal !!

© 2013-2024 SlidesFinder. All rights reserved.

Re-productivity of content are not allowed. Without prior written permission from author, commercial use of any content is illegal.