X

Download Melanoma Symposium PowerPoint Presentation

SlidesFinder-Advertising-Design.jpg

Login   OR  Register
X


Iframe embed code :



Presentation url :

Home / Health & Wellness / Health & Wellness Presentations / Melanoma Symposium PowerPoint Presentation

Melanoma Symposium PowerPoint Presentation

Ppt Presentation Embed Code   Zoom Ppt Presentation

PowerPoint is the world's most popular presentation software which can let you create professional Melanoma Symposium powerpoint presentation easily and in no time. This helps you give your presentation on Melanoma Symposium in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.

The uploader spent his/her valuable time to create this Melanoma Symposium powerpoint presentation slides, to share his/her useful content with the world. This ppt presentation uploaded by onlinesearch in Health & Wellness ppt presentation category is available for free download,and can be used according to your industries like finance, marketing, education, health and many more.

About This Presentation

Melanoma Symposium Presentation Transcript

Slide 1 - Genetic Testing for Melanoma Risk Stratification Sancy Leachman, MD, PhD Assistant ProfessorHuntsman Cancer Institute and the Department of DermatologyUniversity of Utah Health Sciences Center Pacific Dermatologic AssociationAugust 9, 2008
Slide 2 - Hereditary Melanoma Nevus Phenotype: Lots and Atypical
Slide 3 - Hereditary MelanomaNevus Phenotype: Many, Mainly Small
Slide 4 - Hereditary MelanomaNevus Phenotype: Few, Few/No Atypical Phenotype ≠ Genotype
Slide 5 - Other Phenotypic Markers“Constitutional” Risk
Slide 6 - Wild-Type and Homozygous “R” Variant MC1R
Slide 7 - Heterozygous for MC1R Variants Phenotype ≠ Genotype
Slide 8 - Risk EstimationFamily History is Greatest Risk Member of melanoma family 35 – 70 Previous primary melanoma 8.5 Multiple nevi/atypical nevi 2 – 12 Red hair 2.4 – 4 Family history of melanoma 2 – 3 History of blistering sunburn 2 – 3 Freckling 2-3 Blue eyes 1.6 Skin type I 1.4 Factor Relative Risk Kefford RF, et al. J Clin Oncol. 1999;17:3245-3251.
Slide 9 - *Bishop DT et al. J Natl Cancer Inst. 2002;94:894-903. †Rulyak SJ et al. Cancer. 2003;98(4):798-804; and Paker JF et al. Arch Dermatol. 2003;139:1019-1025. p16 Mutation Carriers:Melanoma and Pancreatic Adenocarcinoma p16 Tumor Suppressor controlling the cell cycle Higher lifetime risk of melanoma* United Kingdom: 58% United States: 76% Australia: 91% Increased risk of pancreatic cancer† (11%-17% in some families) Red hair increases risk
Slide 10 - Few Melanomas Are Hereditary
Slide 11 - Case Presentation A dermatologist from Kentucky contacted our genetic counseling group to discuss how to perform genetic testing on a patient: 64 y/o nurse practitioner with dysplastic nevus syndrome, a personal history of melanoma, no children No known family history of melanoma or pancreatic cancer Patient wishes to have p16 genetic testing performed on a self-pay basis Patient is interested in participating in available research protocols for melanoma
Slide 12 - Should Clinical Genetic Testing be Offered to This Patient? Yes No Maybe
Slide 13 - Issues for Consideration Statistically, the patient has only between a 0.2%-2.0% risk of carrying a p16 mutation (Aitken et al, and Begg et al) The patient does NOT have features suggestive of elevated risk for carriage of a p16 mutation (Hansen et al. Lancet Oncology. 2004) Multiple primary melanomas Two or more other family members with melanoma Family member with pancreatic cancer Because she has already had melanoma, there is little chance that a positive or negative test result will alter prevention, early detection, management, or follow-up recommendations She expressed the desire for testing and willingness to pay Knowledge of status may provide psychological benefit to her because of her curiosity and professional background If p16-positive (unlikely), other family members could be tested and pancreatic cancer screening (if available) could be offered Research protocols are available to p16 mutation-tested individuals
Slide 14 - ≥3 melanomas in a family (any degree of relationship) 12%-41% ≥3 melanomas in an individual 5%-23% ≥3 “cancer events” in a family (any combination of melanoma and pancreatic cancer) ~68% Candidates for p16 Testing:“Rule of Threes” *Only 1 criteria needs to be met. Consideration should be given to age of diagnosis, UV exposure, skin type, and ethnicity, as there may be exceptions to the “Rule of Threes.”
Slide 15 - Should Clinical Genetic Testing be Offered to This Patient? Yes No Maybe Answer: Based on typical criteria used to evaluate a patient for genetic testing, the answer is “NO.” However, as with all areas of medicine, there is “art” involved.
Slide 16 - Case Presentation 32 y/o woman with numerous clinically atypical nevi No personal history of melanoma Confirmed family history of invasive melanomain 2 of 6 siblings, and 2 paternal uncles. Her father died from metastatic pancreatic carcinoma She has 3 children (ages 10, 8, and 6 years) Two children have clinically atypical nevi She is NOT interested in participating in an available research protocol for familial melanoma She wishes to have p16 genetic testing performed
Slide 17 - Should Clinical Genetic Testing be Offered to This Patient? Yes No Maybe
Slide 18 - Adapted from ASCO. True negative Inconclusive Answer: NoInterpreting a Negative Result Not Possible
Slide 19 - Should an Affected Member of the Family be Tested? Yes No Maybe
Slide 20 - Issues for Consideration Statistically, the patient’s family has a greater than 50% risk of carrying a p16 mutation Carriers in her family are also likely to be predisposed to pancreatic cancer She expressed the desire for testing If she is not interested in clinical research, there will be little change in management Knowledge of status may provide psychological benefit, especially if negative Knowledge of status may permit lifestyle change and rigorous adherence to prevention and early detection strategies in her children if positive Summary: Benefit of knowledge, little to no risk A family member would be tested in our institution if desired
Slide 21 - p16 Test Reporting Study 45 members of p16 families received test results 19 non-carriers, 26 carriers 23 female, 22 male 43/45 reported benefits or positive aspects to testing 40/45 reported no downside or negative aspects
Slide 22 - Underscreeners 1 SSE/Month (On Target) Overscreeners Receipt of Positive p16 Results Increases Screening P < .0003 P < .023 n.s. Aspinwall et al. Cancer Epidemiol Biomarkers Prev. 2008;17(6):1510-1519.
Slide 23 - How Should it be Done? Identify high-risk patients Get Help First Time Around!! Refer to a research protocol Consult a clinical genetic testing center Find a local center: www.nsgc.org www.cancer.gov/ (National Cancer Institute) Huntsman Cancer Institute: wendy.kohlmann@hci.utah.edu
Slide 24 - Where is Testing Performed? Clinical U.S. genetic laboratories offering p16 genetic testing (some will assist with obtaining insurance approvals) Find details at www.genetests.org Current CLIA certified laboratories GeneDX (USA) Myriad Genetic Laboratories (USA) Yale University School of Medicine (USA)
Slide 25 - How Much Does it Cost? Approximately $750 for first test Site-specific testing about $385 70% who go through pre-authorization receive 90% coverage on average
Slide 26 - Conclusions for Genetic Testing It is difficult to perform clinical genetic testing in the average outpatient setting Patient selection for candidacy is crucial Informed consent and pre- and post-test counseling is important Enrollment of patients in a research protocol for hereditary melanoma is preferable whenever possible, though patients may wish to choose protocols that report results Special situations may arise in which clinical genetic testing is appropriate for a given individual, but should never replace the standard criteria for testing
 

Frequently Asked Questions

> About SlidesFinder?

Slidesfinder is a website that allows users to upload and share their PowerPoint presentations online. It provides a platform for individuals and businesses to share their ideas and knowledge through presentations, and for others to view and download these presentations for educational or professional purposes.
Slidesfinder offers a wide range of presentation topics and categories, including business, education, science, technology, health, and more. Users can also search for presentations using keywords, tags, or by category. The website provides tools to create professional presentations with rich media, animations, and graphics.



One of the key features of Slidesfinder is its user-friendly interface, which allows users to easily upload, view, and share presentations. Users can also embed their presentations in their websites or blogs using the website's embed code feature.
Slidesfinder also offers premium services, such as the ability to create private presentations and to download presentations in high-quality formats. However, the basic features of Slidesfinder are free to use, making it accessible to anyone who wants to share their ideas and knowledge through presentations.

> How do I register with SlidesFinder?

Go to registration page (you can see signup link on top of website page) https://www.slidesfinder.com/signup . If you have facebook/gmail account them just click on SIGN IN WITH FACEBOOK OR SIGN IN WITH GOOGLE button, by this you will be a registered member of slidesfinder without filling any form, required detail automatically will be fatch from your account. If you do not a Facebook account, then click on "Signup". Fill all required fields and you will be a registered member of slidesfinder.

> Is slidesfinder account confirmation is mandatory?

Yes it is mandetory to active your account to login.

> Do I need to signup/login on SlidesFinder before uploading a PowerPoint presentation?

Yes, you need to login with your account before uploading presentation. Your username will be displayed on your uploaded presentation. Your registered email id is needed for sending your stats of uploaded presentation.

Slidesfinder is a sharing website for PowerPoint presentations search and share. Find your interest in the form of powerpoint presentations on slidesfinder and save your valuable time . On Slidesfinder you get presentations from our huge library of professional ppt presentations. We believe in making your search INFORMATIVE and FUN. Find your best ppt presentation from a pool of PowerPoint presentations stacked under important industry categories like business & management, heath & Wellness,eduction & training etc. We provide unique informative PowerPoint presentation for marketers, presenters and educationists. These professional PowerPoint presentations are uploaded by professionals from across numerous industry segments.These ppt presentations are available for FREE download.

Not just finding your interest, but facilitate you broadcast your interest. We have created this platform for easy sharing of PowerPoint presentations, ensuring that these presentations get maximum exposure. Create your slidesfinder account and upload PowerPoint presentations for free, share on social media platforms and BUILD YOUR CROWD WITH PRESENTATION !!

The Great Buddha says, "Share your knowledge.It’s a way to achieve immortality"! So, start sharing knowledge and we are here to make that immortal !!

© 2013-2024 SlidesFinder. All rights reserved.

Re-productivity of content are not allowed. Without prior written permission from author, commercial use of any content is illegal.