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Breast Cancer Research PowerPoint Presentation

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About This Presentation

Slide 1 - Breast Cancer Research, School of Medicine Breast Cancer Research Michael J Kerin | Professor of Surgery & Research Director, NBCRI
Slide 2 - Breast Cancer Research, School of Medicine NCRI Predictions 2005-2035Breast Cancer Incidence in Ireland 2196 2781  137 3484  623 4833 1771 2010-2030: 53% increase in incidence
Slide 3 - Breast Cancer Research, School of Medicine Total No. of Breast Cancer Cases 2003-2010 University Hospital Galway
Slide 4 - Breast Cancer Research, School of Medicine Symptomatic Breast Clinic 2009 Annual Report 2003-2009: number of patients attending the unit increased from 3475 to 9671 Breast cancer diagnoses increased from 110 to 529 per annum 2005-2009: 61-68% of women have been treated with breast conservation surgery 61% of women were given a a post-mastectomy immediate breast reconstruction
Slide 5 - Breast Cancer Research, School of Medicine UHG Breast Clinic Team
Slide 6 - Breast Cancer Research, School of Medicine Breast Cancer Research Laboratory established by Professor Fred Given in 1991 National Breast Cancer Research Institute (NBCRI) charity funding has enabled research development Comprehensive specimens biobank and database chaptering over 20 years of patients National & international scientific and clinical collaborators
Slide 7 - Core Research Projects
Slide 8 - Breast Cancer Research, School of Medicine Postgraduate & Undergraduate Researchers 2005-2011 70% of our student researchers are partially or fully funded by NBCRI
Slide 9 - Breast Cancer Research, School of Medicine Molecular Profiling:Cancer Genes Research Questions? What genes are involved in causing breast cancer? Are genes affected by chemotherapy, radiotherapy etc? Can we develop a cancer gene profile that will improve diagnosis and treatment of breast cancer?
Slide 10 - Breast Cancer Research, School of Medicine Gene & Cell Therapy:Adult Stem Cells Stem cells have the potential to develop into many different cell types in the body Do they develop into cancer cells? Can they be used to target cancer cells? Can cells “home” to bone, lungs?
Slide 11 - Breast Cancer Research, School of Medicine MicroRNA & Gene Profiling Research Team Nicola Miller PhD Research Supervisor Breast Cancer Dr Aoife Lowery PhD Dr Helen Heneghan Dr Nuala Healy Dr Ailbhe McDermott Dr Ronan Glynn Colorectal Cancer Dr Kah Hoong Chang Dr Mary Nugent Prostate Cancer Dr Brian Kelly
Slide 12 - Breast Cancer Research, School of Medicine Stem Cells & Tumour Microenvironment Research Team Roisin Dwyer PhD Research Supervisor Sonja Khan MSc James Ryan MSc Dr Shirley Potter Dr Marion Hartmann Dr Fiachra Martin Dr John Kelly
Slide 13 - Breast Cancer Research, School of Medicine Population Genetics Research Team Nicola Miller PhD Research Supervisor Breast Cancer Dr Niall McInerney Dr Gabrielle Colleran Dr Jemima Dorairaj
Slide 14 - Breast Cancer Research, School of Medicine Breast Cancer Management Research How has the clinical management of breast cancer changed? Minimally invasive diagnostic techniques, screening Breast Conserving Surgery Sentinel Lymph Node Biopsy Oncoplastics & Reconstruction Molecular Biology Research Article published Sept 2009
Slide 15 - Breast Cancer Research, School of Medicine Recent High Impact Publications The Lancet Oncology, March 2011 (Yale Collaboration) Stem CellsJune 2011 (REMEDI, Arizona, Mayo Clinic Collaboration)
Slide 16 - Breast Cancer Research, School of Medicine Recent High Impact Publications JNCI, December 2010 (Oxford Collaboration)
Slide 17 - Breast Cancer Research, School of Medicine International Impact of Publishing Research Clinical Cancer Research 2007 Cited by 91 other studies Annals of Surgery, March 2010 50 citations
Slide 18 - Breast Cancer Research, School of Medicine Clinical and Preclinical Trials Irish Cooperative Research Group (ICORG) Trial opened in May 2011 Investigating the effect of neoadjuvant therapy on microRNA expression in breast cancer Preclinical Translational Trials in Animal Models We are translating what we have found in the lab to an in vivo model. The animal facility is based in REMEDI, NUI Galway. Strict ethical guidelines regulate this field of research
Slide 19 - Breast Cancer Research, School of Medicine Research Collaborators International Yale University, USA (Dr Frank Slack) University of Arizona (Dr Harrison Barrett) The Mayo Clinic, US (Dr John Morris) University of Oxford (Prof Ian Tomlinson, Dr Ellie Sawyer) European Molecular Biology Laboratory, Germany (Dr Vladimir Benes) Nottingham Trent University, UK (Dr Graham Ball) Baylor University, Texas (Kent Osborne, Rachel Schiff) National Biomedical Diagnostic Institutes, DCU Local Molecular Diagnostic Research Group, NUI Galway (Dr. Tom Barry) REMEDI, NUI Galway (Prof Tim O’Brien, Prof Frank Barry) Clinical Research Facility Biostatistics Unit (Dr John Newell)
Slide 20 - Breast Cancer Research, School of Medicine Funding Income 2004-2011
Slide 21 - Breast Cancer Research, School of Medicine Recent Funding Awards Breast Cancer Campaign, UK €100,000 (2011-2015) SFI Biomedical Diagnostic Institute €400,000 (2011-2015) Postdoctoral Scientist and Research Assistant employed in April 2011 in collaboration with Molecular Diagnostics Research Group
Slide 22 - Breast Cancer Research, School of Medicine How your money is spent
Slide 23 - Breast Cancer Research, School of Medicine UHG Clinical Breast Service Breast Research Facilities
Slide 24 - Breast Cancer Research, School of Medicine Translation Research Facility:Breast Cancer Research for the Future Architect image of TRF. To be located on UHG campus Cois Coiribe 2009: NUI Galway Alumni Publication
Slide 25 - Breast Cancer Research, School of Medicine Breast Cancer Biobank Collection of patient specimens and data that may be used for research Ethically approved Patient Consent Largest breast cancer biobank in Ireland Over 4000 patients registered Multiple specimens per patient
Slide 26 - Breast Cancer Research, School of Medicine Fundraising Groups: Friends of NBCRI Galway – Anna O’Coinne Mullingar – Joe Duffy Dublin – Goretti Newell, Miriam Hand Sligo – Oonagh Monahan Ennis – Monica Gallagher Castlebar –Lourda McHugh ICA, ILGU, Jim Bolger
Slide 27 - Breast Cancer Research, School of Medicine NBCRI Fundraising Events Into the West Cycle (Mullingar to Galway…and back!)
Slide 28 - Breast Cancer Research, School of Medicine Tea at the GOct 2010(Afternoon Tea/Fashion Show) Cois Cladaigh Christmas Concert December 2010
Slide 29 - Breast Cancer Research, School of Medicine NBCRI Fundraising Events California Walking Challenge 2010 2011 Destinations Sweden (July) New York (November)
Slide 30 - Breast Cancer Research, School of Medicine Other NBCRI Fundraising Events National Sponsored Cycles, Walks, Marathons Table Quizzes, Race nights Fashion shows Coffee mornings, lunches Supermarket bag pack Car Wash Golf AM-AM Gala Dinners (e.g. Valentine’s Ball, Galway) Auctions Record breaking – Get in the Guinness Book of Records and help breast cancer Research!
Slide 31 - Breast Cancer Research, School of Medicine For more information… Website @ www.nbcri.ie Research Newsletter 2011
Slide 32 - Radical Mastectomy 2010 1900 1980 1970 Fisher NSABP Tamoxifen Simple Mastectomy CMFCAF Her2neu Taxotere Molecular Classification
Slide 33 - Breast Cancer Research, School of Medicine Future Developments Breast Cancer care will continue to improve with individualisation of therapy High volume unit improves patient outcomes Enhanced specialist expertise of next generation by combining science and medicine for patient benefit Local and National Research Collaborators Quality International Research Output from West of Ireland
 

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