X

Download Artificial White Blood Cell PowerPoint Presentation

SlidesFinder-Advertising-Design.jpg

Login   OR  Register
X


Iframe embed code :



Presentation url :

Home / Health & Wellness / Health & Wellness Presentations / Artificial White Blood Cell PowerPoint Presentation

Artificial White Blood Cell PowerPoint Presentation

Ppt Presentation Embed Code   Zoom Ppt Presentation

PowerPoint is the world's most popular presentation software which can let you create professional Artificial White Blood Cell powerpoint presentation easily and in no time. This helps you give your presentation on Artificial White Blood Cell in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.

The uploader spent his/her valuable time to create this Artificial White Blood Cell powerpoint presentation slides, to share his/her useful content with the world. This ppt presentation uploaded by worldwideweb in Health & Wellness ppt presentation category is available for free download,and can be used according to your industries like finance, marketing, education, health and many more.

About This Presentation

Slide 1 - Artificial White Blood Cell Doug Tischer 1
Slide 2 - Artificial White Blood Cell Doug Tischer 1 The Big Idea Our engineered cells will “explode” when they detect a “bad” cell, killing both itself and the nearby bad cell. The “explosion” is a sudden burst of H2O2, similar to a neutrophil’s oxidative burst. The bad cell will be detected when it attempts to conjugate with our cell. This ensures it is physically close, and will be killed by the oxidative burst. 2
Slide 3 - Artificial White Blood Cell Doug Tischer 1 The Big Idea Our engineered cells will “explode” when they detect a “bad” cell, killing both itself and the nearby bad cell. The “explosion” is a sudden burst of H2O2, similar to a neutrophil’s oxidative burst. The bad cell will be detected when it attempts to conjugate with our cell. This ensures it is physically close, and will be killed by the oxidative burst. 2 Genetic Construction Cre recombinase translation is allowed only in the presence of tetracylcine resistance transcripts. Can riboswitches also be unlocked by ssDNA, as occurs during plasmid transfer during conjugation? Xanthine oxidase requires trypsin processing to be active. Trypsin expression must be tightly controlled. Any bacterial promoter would be to leaky. trypsin xod cre (riboregulated) 3
Slide 4 - Artificial White Blood Cell Doug Tischer 1 The Big Idea Our engineered cells will “explode” when they detect a “bad” cell, killing both itself and the nearby bad cell. The “explosion” is a sudden burst of H2O2, similar to a neutrophil’s oxidative burst. The bad cell will be detected when it attempts to conjugate with our cell. This ensures it is physically close, and will be killed by the oxidative burst. 2 Genetic Construction Cre recombinase translation is allowed only in the presence of tetracylcine resistance transcripts. Can riboswitches also be unlocked by ssDNA, as occurs during plasmid transfer during conjugation? Xanthine oxidase requires trypsin processing to be active. Trypsin expression must be tightly controlled. Any bacterial promoter would be to leaky. trypsin xod cre (riboregulated) 3 Mechanism 1. The cells 2. Conjugation tetR “Bad Cell” “Engineered WBC” tetR trypsin xan. oxidase (inactive) 4
Slide 5 - Artificial White Blood Cell Doug Tischer 1 The Big Idea Our engineered cells will “explode” when they detect a “bad” cell, killing both itself and the nearby bad cell. The “explosion” is a sudden burst of H2O2, similar to a neutrophil’s oxidative burst. The bad cell will be detected when it attempts to conjugate with our cell. This ensures it is physically close, and will be killed by the oxidative burst. 2 Genetic Construction Cre recombinase translation is allowed only in the presence of tetracylcine resistance transcripts. Can riboswitches also be unlocked by ssDNA, as occurs during plasmid transfer during conjugation? Xanthine oxidase requires trypsin processing to be active. Trypsin expression must be tightly controlled. Any bacterial promoter would be to leaky. trypsin xod cre (riboregulated) 3 Mechanism 1. The cells 2. Conjugation tetR “Bad Cell” “Engineered WBC” tetR trypsin xan. oxidase (inactive) 4 Mechanism Cont. 3. Hydrogen Peroxide Production 4. Death! tetR xan. oxidase (active) H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 5
Slide 6 - Artificial White Blood Cell Doug Tischer 1 The Big Idea Our engineered cells will “explode” when they detect a “bad” cell, killing both itself and the nearby bad cell. The “explosion” is a sudden burst of H2O2, similar to a neutrophil’s oxidative burst. The bad cell will be detected when it attempts to conjugate with our cell. This ensures it is physically close, and will be killed by the oxidative burst. 2 Genetic Construction Cre recombinase translation is allowed only in the presence of tetracylcine resistance transcripts. Can riboswitches also be unlocked by ssDNA, as occurs during plasmid transfer during conjugation? Xanthine oxidase requires trypsin processing to be active. Trypsin expression must be tightly controlled. Any bacterial promoter would be to leaky. trypsin xod cre (riboregulated) 3 Mechanism 1. The cells 2. Conjugation tetR “Bad Cell” “Engineered WBC” tetR trypsin xan. oxidase (inactive) 4 Mechanism Cont. 3. Hydrogen Peroxide Production 4. Death! tetR xan. oxidase (active) H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 5 Advantages Xanthine oxidase naturally requires trypsin processesing to be active. H2O2 is naturally used by neutrophils to kill bacteria. Conjugation typically lasts ~100 minutes. The bacteria should be close together long enough for the H2O2 to be produced in large amounts. 6
Slide 7 - Artificial White Blood Cell Doug Tischer 1 The Big Idea Our engineered cells will “explode” when they detect a “bad” cell, killing both itself and the nearby bad cell. The “explosion” is a sudden burst of H2O2, similar to a neutrophil’s oxidative burst. The bad cell will be detected when it attempts to conjugate with our cell. This ensures it is physically close, and will be killed by the oxidative burst. 2 Genetic Construction Cre recombinase translation is allowed only in the presence of tetracylcine resistance transcripts. Can riboswitches also be unlocked by ssDNA, as occurs during plasmid transfer during conjugation? Xanthine oxidase requires trypsin processing to be active. Trypsin expression must be tightly controlled. Any bacterial promoter would be to leaky. trypsin xod cre (riboregulated) 3 Mechanism 1. The cells 2. Conjugation tetR “Bad Cell” “Engineered WBC” tetR trypsin xan. oxidase (inactive) 4 Mechanism Cont. 3. Hydrogen Peroxide Production 4. Death! tetR xan. oxidase (active) H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 5 Advantages Xanthine oxidase naturally requires trypsin processesing to be active. H2O2 is naturally used by neutrophils to kill bacteria. Conjugation typically lasts ~100 minutes. The bacteria should be close together long enough for the H2O2 to be produced in large amounts. 6 Alternatives/Improvements Better detection system. Riboswitches can be leaky, but would allow for detection of a wide variety of antibiotic resistant strains. Alternatives to xanthine oxidase Glucose oxidase: dimeric, well studied NADH oxidsase: produces H2O2 outside cell membrane. 7 subunit integral protein. Induce phage to kill other bacteria. 7
Slide 8 - Artificial White Blood Cell Doug Tischer 1 The Big Idea Our engineered cells will “explode” when they detect a “bad” cell, killing both itself and the nearby bad cell. The “explosion” is a sudden burst of H2O2, similar to a neutrophil’s oxidative burst. The bad cell will be detected when it attempts to conjugate with our cell. This ensures it is physically close, and will be killed by the oxidative burst. 2 Genetic Construction Cre recombinase translation is allowed only in the presence of tetracylcine resistance transcripts. Can riboswitches also be unlocked by ssDNA, as occurs during plasmid transfer during conjugation? Xanthine oxidase requires trypsin processing to be active. Trypsin expression must be tightly controlled. Any bacterial promoter would be to leaky. trypsin xod cre (riboregulated) 3 Mechanism 1. The cells 2. Conjugation tetR “Bad Cell” “Engineered WBC” tetR trypsin xan. oxidase (inactive) 4 Mechanism Cont. 3. Hydrogen Peroxide Production 4. Death! tetR xan. oxidase (active) H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 H2O2 5 Advantages Xanthine oxidase naturally requires trypsin processesing to be active. H2O2 is naturally used by neutrophils to kill bacteria. Conjugation typically lasts ~100 minutes. The bacteria should be close together long enough for the H2O2 to be produced in large amounts. 6 Alternatives/Improvements Better detection system. Riboswitches can be leaky, but would allow for detection of a wide variety of antibiotic resistant strains. Alternatives to xanthine oxidase Glucose oxidase: dimeric, well studied NADH oxidsase: produces H2O2 outside cell membrane. 7 subunit integral protein. Induce phage to kill other bacteria. 7 References Stirpe, F., and Della Corte, E., Regulation of Rat Liver Xanthine Oxidase. J. Biol. Chem., 244, 3855-3863 (1969). Harrison, R., Structure and Function of Xanthine Oxidoreductase: Where are we now? Free Radical Biology & Medicine., 33, 774-797 (2002). 8
 

Frequently Asked Questions

> About SlidesFinder?

Slidesfinder is a website that allows users to upload and share their PowerPoint presentations online. It provides a platform for individuals and businesses to share their ideas and knowledge through presentations, and for others to view and download these presentations for educational or professional purposes.
Slidesfinder offers a wide range of presentation topics and categories, including business, education, science, technology, health, and more. Users can also search for presentations using keywords, tags, or by category. The website provides tools to create professional presentations with rich media, animations, and graphics.



One of the key features of Slidesfinder is its user-friendly interface, which allows users to easily upload, view, and share presentations. Users can also embed their presentations in their websites or blogs using the website's embed code feature.
Slidesfinder also offers premium services, such as the ability to create private presentations and to download presentations in high-quality formats. However, the basic features of Slidesfinder are free to use, making it accessible to anyone who wants to share their ideas and knowledge through presentations.

> How do I register with SlidesFinder?

Go to registration page (you can see signup link on top of website page) https://www.slidesfinder.com/signup . If you have facebook/gmail account them just click on SIGN IN WITH FACEBOOK OR SIGN IN WITH GOOGLE button, by this you will be a registered member of slidesfinder without filling any form, required detail automatically will be fatch from your account. If you do not a Facebook account, then click on "Signup". Fill all required fields and you will be a registered member of slidesfinder.

> Is slidesfinder account confirmation is mandatory?

Yes it is mandetory to active your account to login.

> Do I need to signup/login on SlidesFinder before uploading a PowerPoint presentation?

Yes, you need to login with your account before uploading presentation. Your username will be displayed on your uploaded presentation. Your registered email id is needed for sending your stats of uploaded presentation.

Slidesfinder is a sharing website for PowerPoint presentations search and share. Find your interest in the form of powerpoint presentations on slidesfinder and save your valuable time . On Slidesfinder you get presentations from our huge library of professional ppt presentations. We believe in making your search INFORMATIVE and FUN. Find your best ppt presentation from a pool of PowerPoint presentations stacked under important industry categories like business & management, heath & Wellness,eduction & training etc. We provide unique informative PowerPoint presentation for marketers, presenters and educationists. These professional PowerPoint presentations are uploaded by professionals from across numerous industry segments.These ppt presentations are available for FREE download.

Not just finding your interest, but facilitate you broadcast your interest. We have created this platform for easy sharing of PowerPoint presentations, ensuring that these presentations get maximum exposure. Create your slidesfinder account and upload PowerPoint presentations for free, share on social media platforms and BUILD YOUR CROWD WITH PRESENTATION !!

The Great Buddha says, "Share your knowledge.It’s a way to achieve immortality"! So, start sharing knowledge and we are here to make that immortal !!

© 2013-2024 SlidesFinder. All rights reserved.

Re-productivity of content are not allowed. Without prior written permission from author, commercial use of any content is illegal.