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White Blood Corpuscles PowerPoint Presentation

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White Blood Corpuscles Presentation Transcript

Slide 1 - White Blood Cells
Slide 2 - Blood components All blood cells arise from the same stem cell. In response to various chemical messengers, called cytokines, the stem cells begin to differentiate into one of two types, myeloid or lymphoid. Further differentiation in response to additional cytokines results in forming cell types. The primary cytokine responsible for erythrocyte production is erythropoietin (EPO)
Slide 3 - The myeloid line differentiates into erythroblasts which become erythrocytes, megakaryoblasts, which become platelets, and the myeloblast, which become granulocytes and monocytes. The lymphoid line differentiates into lymphoblasts which become lymphocytes.
Slide 4 - ppt slide no 4 content not found
Slide 5 - Left and right shift
Slide 6 - WBC count A total white blood cell count is not necessarily indicative of the severity of a disease, since some serious ailments may show a low white cell count. For this reason, a differential white cell count is performed. A differential white cell count consists of an examination of blood to determine the presence and the number of different types of white blood cells. This study often provides helpful information in determining the severity and extent of an infection, more than any other single procedure used in the examination of the blood.
Slide 7 - WBC Mature and immature neutrophils, lymphocyte, monocytes, eosinophils and basophils make up the leukocytes (WBCs) found on the blood of most mammals. Each type of cell plays an important role in the body’s defense system , and the total concentration of each type is extremely valuable in the diagnosis of various diseases. Definitions page 44 read it.
Slide 8 - How Do WBC Work? http://www.youtube.com/watch?v=KiLJl3NwmpU&NR=1&feature=fvwp-Macrophage http://www.youtube.com/watch?v=ce0Xndms1bc http://www.youtube.com/watch?v=k_GPGrl5HDM&feature=related
Slide 9 - Neutrophil: front line in battle These are usually the most numerous leukocytes in the blood and are primarily responsible for fighting infections
Slide 10 - Granulocytes: Neutrophils
Slide 11 - Segmented neutrophil: Mature cells that have a segmented, irregular shaped nucleus.
Slide 12 - lymphocyte Segmented neutrophil eosinophil
Slide 13 - Band Neutrophil: An immature cell characterized by a horseshoe shaped nucleus
Slide 14 - Hyper-segmented neutrophil: A ‘senior’ cell that is characterized by having 5 or more ‘lobes’ in the nucleus.
Slide 15 - Lymphocyte: guard dog of the body These are the second most common leukocyte in the blood and their primary function is immune regulation.
Slide 16 - In the mature cell, the nucleus is round and occupies most of the cell. These cells will be slightly smaller than neutrophils
Slide 17 - lymphocyte lymphoblast
Slide 18 - Monocyte: buzzard in the blood These are the third most common cell seen in the blood and they have diverse functions. The primary function is to seek out invaders and eat them.
Slide 19 - Once they have been called to help fight an infection, the monocyte will move into the tissue and transform into a macrophage (big eater). They can complete this transformation in about 24 hours http://www.youtube.com/watch?v=tPT_bG6ASGs&feature=related
Slide 20 - Eosinophil: the allergy slayer Eosinophil : red granules compare the color to the erythrocytes
Slide 21 - Under normal conditions, they do not return to circulation after reaching the tissue. There are 300 – 400 eosinophils in the bone marrow for every one circulating in the blood.
Slide 22 - Eosinophils are attracted to tissues where there is a high histamine release. Eosinophils are parasitocidal (destroy parasites), bacteriocidal (destroy bacteria) and phagocitic.
Slide 23 - Basophils: the unknown stranger Basophils have a poorly defined function and are relatively rare in canine and feline blood
Slide 24 - They are produced in the bone marrow and have a life span of 10 to 12 days
Slide 25 - Basophils contain heparin in a bound form with histamine, serotonin, and hyaluronic acid., all of which are easily released
Slide 26 - Leukocyte Disorders Leukocytosis is an increase in the total leukocyte count above the normal upper limit for the animal species. This increase is usually a consequence of an in crease in the total number of circulating neutrophils, although other cell types may also be increased. This increase in leukocytes can be caused by a normal physiologic response or a disease condition.
Slide 27 - Leukocyte Disorders Leukopenia is a decrease in the total number of leukocytes. It may be balanced, a decrease in all cellular elements, or it may be confined to a single element. It is most likely to occur if there is an overwhelming microbial infection or viral induced disease. This decrease occurs as neutrophils move into tissues
Slide 28 - The general causes of neutropenia are related to alteration in the bone marrow and are known as the three D’s Degeneration (ineffective cell formation) Depression (reduced cell formation) Depletion (reduced survival in blood) Degeneration of the marrow is usually the result of a condition that causes deficiency.
Slide 29 - Leukocyte response to steroids Glucocorticoids produce leukocyte alterations that are specific to each animal species Canine: In the dog, increased glucocorticoid steroids produce a three to four fold increase in neutrophils and a simultaneous 50 – 60% reduction in lymphocytes along with the disappearance of eosinophils Feline: The cat responds in a similar way to the dog. An increase in neutrophils, decrease in lymphocytes and some elevation in monocytes will be seen.
Slide 30 - Thank You
 

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